Background: Neurological diseases have always been one of the leading cause of
mobility and mortality world-widely. However, it is still lacking efficient agents. Agmatine,
an endogenous polyamine, exerts its diverse biological characteristics and therapeutic potential in
Methods: This review would focus on the neuroprotective actions of agmatine and its potential
mechanisms in the setting of neurological diseases.
Results: Numerous studies had demonstrated the neuroprotective effect of agmatine in varied types
of neurological diseases, including acute attack (stroke and trauma brain injury) and chronic neurodegenerative
diseases (Parkinson's disease, Alzheimer’s disease). The potential mechanism of
agmatine induced neuroprotection includes anti-oxidation, anti-apoptosis, anti-inflammation, brain
blood barrier (BBB) protection and brain edema prevention.
Conclusions: The safety and low incidence of adverse effects indicate the vast potential therapeutic
value of agmatine in the treatment of neurological diseases. However, most of the available studies
relate to the agmatine are conducted in experimental models, more clinical trials are needed before
the agmatine could be extensively clinically used.