Title:Emerging Molecular Targets for Anti-Cancer Drug Design
VOLUME: 12 ISSUE: 1
Author(s):Rohit Dutt, Vandana Garg and Anil K. Madan*
Affiliation:Department of Pharmacy, G.D. Goenka University, Gurgaon-122103, Department of Pharmaceutical Sciences, M.D. University, Rohtak-124001, Faculty of Pharmaceutical Sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak-124001
Keywords:Cancer therapy, molecular targets, anti-cancer agents, oncogenes, drug design, novel molecular target.
Abstract:Background: Interest in targeting metabolism as a viable cancer therapy has been revived in
last decade. This has significantly contributed to the understanding of the altered metabolic profile of
proliferating cancer cells. Clinically launched target specific drugs have shown encouraging results in
terms of both efficacy and safety than conventional anticancer drugs.
Objective: Targeted approaches have significantly changed the treatment of cancer and substantially
improved life expectancy of cancer patients. Moreover, the continual discovery of novel molecular targets
against various cancer subtypes (lung, breast, colon, prostate, pancreatic cancer etc.) has enabled
early diagnosis and treatment of patients against this dreadful disease. Identification of novel cancer biomarkers
may aid in the development of new anti-cancer therapies and treatment strategies.
Conclusion: Molecular mechanism and clinical efficacy of some of the emerging molecular targets for
cancer chemotherapy have been briefly reviewed in the present article.
