Background & Objective: Brain areas of functional activation during emotional stimuli and
their correlations with affective temperaments evaluated using Temperament Evaluation of Memphis,
Pisa, Paris and San Diego (TEMPS-A) and hopelessness levels assessed with the Beck Hopelessness
Scale (BHS) have been investigated.
Method: Brain activity in response to emotional stimuli was examined by Nuclear Magnetic Resonance
Blood Oxygen Level Dependent (NMR BOLD) signal. Seventeen subjects (mean age ± SD = 57
± 12), diagnosed with major affective disorders and eighteen healthy controls (HC) (mean age ± SD =
50±11) participated in this study. Higher functional activation of the left amygdala and cingulated
gyrus was found in subjects with affective disorders; whereas, the right amygdala was mostly activated
in the HC group. Higher BHS scores were associated with reduced BOLD activation throughout
the primary somatosensorial cortex and left post-central gyrus.
Conclusion: Conversely, increased BOLD activation throughout the parietal superior lobule and right
anterior intraperietal sulcus, occipital cortex, and left optical radiation, right insular cortex, right frontal
superior gyrus was correlated with higher BHS total scores. Future studies should investigate the nature
of the associations among brain activation, suicide risk, and affective temperaments in larger samples.