Background: Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure
for the treatment of obesity.
Objectives: The present study aimed to assess the effects of SG on the metabolic and inflammatory
profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with
obesity induced by a high-fat diet.
Methods: Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or
sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and
RAS components in adipose tissue were evaluated.
Results: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p
< 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition,
SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin-
6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme
(ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p <
0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p =
0.10) and Mas (p = 0.22) receptors.
Conclusion: This study showed that SG leads to weight loss and improves metabolic parameters.
Changes in the expression of RAS components and of inflammatory molecules in adipose tissue
seem to play a role the before beneficial effects of the SG.