Background: Many physiological responses of the Renin Angiotensin System (RAS) are
associated with two opposite pathways: (1) a classical one formed by angiotensin-converting enzyme
(ACE), Angiotensin II (Ang II) and Angiotensin type 1 (AT1) receptor, which is associated to
vasoconstriction, cell proliferation, organ hypertrophy, sodium retention and aldosterone release
and (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2
(ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation,
anti-hypertrophy, cardioprotective and renoprotective actions.
Objective: This review aimed to bring up-to-date on the interactions between physical exercise and
the vasodilator axis of the RAS (ACE2-Ang-(1-7)-Mas receptor axis). We also investigated the
relation of acute and chronic exercise with blood pressure regulation and components of the vasodilator
axis of the RAS.
Methods: We searched studies with animal models and humans in PUBMED, LILACS and IBECS.
Results: Experimental studies showed that physical training can stimulate ACE2-Ang-(1-7)-Mas
receptor axis in parallel with the inhibition of ACE-Ang II-AT1 receptor pathway. However, up to
now, the interaction between the counter-regulatory RAS axis and physical training is not investigated
Conclusion: The activation of ACE2-Ang-(1-7)-Mas receptor axis may have a role in the beneficial
effects of physical training in experimental models. Further studies with humans are necessary.