Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells

Author(s): Maria Ines Herrera*, Sofia Mucci*, George E. Barreto, Rodolfo Kolliker-Frers, Francisco Capani*.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 26 , 2017

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Abstract:

Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.

Keywords: brain injury, hypoxia-ischemia, pharmacological treatments, glial cells, neuroprotection

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Article Details

VOLUME: 23
ISSUE: 26
Year: 2017
Page: [3899 - 3906]
Pages: 8
DOI: 10.2174/1381612823666170727145422
Price: $58

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