Post Cardiovascular Surgery Atrial Fibrillation. Biomarkers Determining Prognosis

Author(s): Olivia Manfrini, Edina Cenko, Beatrice Ricci, Raffaele Bugiardini*.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 5 , 2019

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Abstract:

Background: New onset of atrial fibrillation (AF) after cardiovascular surgery is associated with increased risk of complications and length of hospital stay. Identification of patients at high risk of post-operative AF (POAF) may help to act with preventive strategies having clinical and economic relevance.

Objective: The focus of this review is to summarize findings on biomarkers of myocardial fibrosis (PICP and PIIINP), profibrotic mediators (TGF-beta1), extracellular matrix remodeling (MMP-9), myocardial stretch (BNP and NTpro-BNP), inflammation (interleukins, C-reactive protein and sCD40L), and myocardial necrosis (high-sensitivity troponin T), biomarkers, that can be used in clinical practice to stratify patients at risk for POAF.

Method: We searched English-language studies on MEDLINE and PubMed. Evidence synthesis was based on cohort studies, clinical trials and meta-analysis data. International clinical practice guidelines were reviewed, as well.

Results: Factors such as cardiac remodelling, atrial pressure, surgery trauma, inflammation, oxidative stress, and sympathetic/parasympathetic activation have been implicated in the development of POAF. On the basis of multifactorial mechanism underlying the onset of POAF, several studies have investigated the predictive value of some serum biomarkers. To date, there are promising preliminary data on the clinical utility of PICP, PIINP, TGF-β1 and sCD40L, whereas data on NT-proBNP, BNP, CRP, IL- 6, and hs-cTnT are controversial.

Conclusion: Although some studies have shown promising results, there is a need for future larger studies with longer follow-up, before applying biomarkers as tools for POAF risk-stratification into clinical practice.

Keywords: Atrial fibrillation, post-operative atrial fibrillation, collagen synthesis, brain natriuretic peptide, interleukin, inflammation.

[1]
Echahidi, N.; Pibarot, P.; O’Hara, G.; Mathieu, P. Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery. J. Am. Coll. Cardiol., 2008, 51(8), 793-801.
[2]
Villareal, R.P.; Hariharan, R.; Liu, B.C.; Kar, B.; Lee, V.V.; Elayda, M.; Lopez, J.A.; Rasekh, A.; Wilson, J.M.; Massumi, A. Postoperative atrial fibrillation and mortality after coronary artery bypass surgery. J. Am. Coll. Cardiol., 2004, 43(5), 742-748.
[3]
Ommen, S.R.; Odell, J.A.; Stanton, M.S. Atrial arrhythmias after cardiothoracic surgery. N. Engl. J. Med., 1997, 336(20), 1429-1434.
[4]
Turagam, M.K.; Mirza, M.; Werner, P.H.; Sra, J.; Kress, D.C.; Tajik, A.J.; Jahangir, A. Circulating biomarkers predictive of postoperative atrial fibrillation. Cardiol. Rev., 2016, 24(2), 76-87.
[5]
Manfrini, O.; Bazzocchi, G.; Luati, A.; Borghi, A.; Monari, P.; Bugiardini, R. Coronary spasm reflects inputs from adjacent esophageal system. Am. J. Physiol. Heart Circ. Physiol., 2006, 290(5), H2085-H2091.
[6]
Ahn, H.J.; Sim, W.S.; Shim, Y.M.; Kim, J.A. Thoracic epidural anesthesia does not improve the incidence of arrhythmias after transthoracic esophagectomy. Eur. J. Cardiothorac. Surg., 2005, 28(1), 19-21.
[7]
Almassi, G.H.; Schowalter, T.; Nicolosi, A.C.; Aggarwal, A.; Moritz, T.E.; Henderson, W.G.; Tarazi, R.; Shroyer, A.L.; Sethi, G.K.; Grover, F.L.; Hammermeister, K.E. Atrial fibrillation after cardiac surgery: a major morbid event? Ann. Surg., 1997, 226(4), 501-511.
[8]
Cox, J.L. A perspective of postoperative atrial fibrillation in cardiac operations. Ann. Thorac. Surg., 1993, 56(3), 405-409.
[9]
Gulielmos, V.; Menschikowski, M.; Dill, H.; Eller, M.; Thiele, S.; Tugtekin, S.M.; Jaross, W.; Schueler, S. Interleukin-1, interleukin-6 and myocardial enzyme response after coronary artery bypass grafting - a prospective randomized comparison of the conventional and three minimally invasive surgical techniques. Eur. J. Cardiothorac. Surg., 2000, 18(5), 594-601.
[10]
Spyrou, N.; Khan, M.A.; Rosen, S.D.; Foale, R.; Davies, D.W.; Sogliani, F.; Stanbridge, R.D.; Camici, P.G. Persistent but reversible coronary microvascular dysfunction after bypass grafting. Am. J. Physiol. Heart Circ. Physiol., 2000, 279(6), H2634-H2640.
[11]
Pries, A.R.; Badimon, L.; Bugiardini, R.; Camici, P.G.; Dorobantu, M.; Duncker, D.J.; Escaned, J.; Koller, A.; Piek, J.J.; de Wit, C. Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation. Eur. Heart J., 2015, 36(45), 3134-3146.
[12]
Heper, G.; Korkmaz, M.E.; Kilic, A. Reperfusion arrhythmias: are they only a marker of epicardial reperfusion or continuing myocardial ischemia after acute myocardial infarction? Angiology, 2007, 58(6), 663-670.
[13]
Cenko, E.; Ricci, B.; Kedev, S.; Kalpak, O.; Câlmâc, L.; Vasiljevic, Z.; Knežević, B.; Dilic, M.; Miličić, D.; Manfrini, O.; Koller, A.; Dorobantu, M.; Badimon, L.; Bugiardini, R. The no-reflow phenomenon in the young and in the elderly. Int. J. Cardiol., 2016, 222, 1122-1128.
[14]
Lim, H.E.; Choi, C.U.; Na, J.O.; Choi, J.I.; Kim, S.H.; Kim, J.W.; Kim, E.J.; Han, S.W.; Park, S.W.; Rha, S.W.; Park, C.G.; Seo, H.S.; Oh, D.J.; Hwang, C.; Kim, Y.H. Effects of iatrogenic myocardial injury on coronary microvascular function in patients undergoing radiofrequency catheter ablation of atrial fibrillation. Circ Arrhythm Electrophysiol, 2013, 6(2), 318-326.
[15]
Lee, R. Atrial fibrillation and flutter after cardiac surgery., 2016. Avaiable at: https://www.uptodate.com/contents/ atrial-fibrillation-and-flutter-after-cardiac-surgery#H11
[16]
Maisel, W.H.; Rawn, J.D.; Stevenson, W.G. Atrial fibrillation after cardiac surgery. Ann. Intern. Med., 2001, 135(12), 1061-1073.
[17]
Tsikouris, J.P.; Kluger, J.; Song, J.; White, C.M. Changes in P-wave dispersion and P-wave duration after open heart surgery are associated with the peak incidence of atrial fibrillation. Heart Lung, 2001, 30(6), 466-471.
[18]
Dupont, E.; Ko, Y.; Rothery, S.; Coppen, S.R.; Baghai, M.; Haw, M.; Severs, N.J. The gap-junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation. Circulation, 2001, 103(6), 842-849.
[19]
Karaca, M.; Demirbas, M.I.; Biceroglu, S.; Cevik, A.; Cetin, Y.; Arpaz, M.; Yilmaz, H. Prediction of early postoperative atrial fibrillation after cardiac surgery: is it possible? Cardiovasc. J. Afr., 2012, 23(1), 34-36.
[20]
Dhurandhar, V.; Saxena, A.; Parikh, R.; Vallely, M.P.; Wilson, M.K.; Butcher, J.K.; Black, D.A.; Tran, L.; Reid, C.M.; Bannon, P.G. Outcomes of on-pump versus off-pump coronary artery bypass graft surgery in the high risk (AusSCORE > 5). Heart Lung Circ., 2015, 24(12), 1216-1224.
[21]
Andrews, T.C.; Reimold, S.C.; Berlin, J.A.; Antman, E.M. Prevention of supraventricular arrhythmias after coronary artery bypass. A meta-analysis of randomized control trial. Circulation, 1991, 84, III236-III244.
[22]
Aranki, S.F.; Shaw, D.P.; Adams, D.H.; Rizzo, R.J.; Couper, G.S.; VanderVliet, M.; Collins, J.J., Jr; Cohn, L.H.; Burstin, H.R. Predictors of atrial fibrillation after coronary artery surgery. Current trends and impact on hospital resources. Circulation, 1996, 94(3), 390-397.
[23]
Creswell, L.L.; Schuessler, R.B.; Rosenbloom, M.; Cox, J.L. Hazards of postoperative atrial arrhythmias. Ann. Thorac. Surg., 1993, 56(3), 539-549.
[24]
Mathew, J.P.; Fontes, M.L.; Tudor, I.C.; Ramsay, J.; Duke, P.; Mazer, C.D.; Barash, P.G.; Hsu, P.H.; Mangano, D.T. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA, 2004, 291(14), 1720-1729.
[25]
Fuller, J.A.; Adams, G.G.; Buxton, B. Atrial fibrillation after coronary artery bypass grafting. Is it a disorder of the elderly? J. Thorac. Cardiovasc. Surg., 1989, 97(6), 821-825.
[26]
Lauer, M.S.; Eagle, K.A.; Buckley, M.J.; DeSanctis, R.W. Atrial fibrillation following coronary artery bypass surgery. Prog. Cardiovasc. Dis., 1989, 31(5), 367-378.
[27]
Wyse, D.G.; Waldo, A.L.; DiMarco, J.P.; Domanski, M.J.; Rosenberg, Y.; Schron, E.B.; Kellen, J.C.; Greene, H.L.; Mickel, M.C.; Dalquist, J.E.; Corley, S.D. A comparison of rate control and rhythm control in patients with atrial fibrillation. N. Engl. J. Med., 2002, 347(23), 1825-1833.
[28]
Al-Sarraf, N.; Thalib, L.; Hughes, A.; Tolan, M.; Young, V.; McGovern, E. Effect of preoperative atrial fibrillation on postoperative outcome following cardiac surgery. Cardiol. Res. Pract., 2012, 2012, 272384.
[29]
Swartz, M.F.; Fink, G.W.; Lutz, C.J.; Taffet, S.M.; Berenfeld, O.; Vikstrom, K.L.; Kasprowicz, K.; Bhatta, L.; Puskas, F.; Kalifa, J.; Jalife, J. Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery. Heart Rhythm, 2009, 6(10), 1415-1422.
[30]
Tanaka, K.; Zlochiver, S.; Vikstrom, K.L.; Yamazaki, M.; Moreno, J.; Klos, M.; Zaitsev, A.V.; Vaidyanathan, R.; Auerbach, D.S.; Landas, S.; Guiraudon, G.; Jalife, J.; Berenfeld, O.; Kalifa, J. Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ. Res., 2007, 101(8), 839-847.
[31]
Swartz, M.F.; Fink, G.W.; Sarwar, M.F.; Hicks, G.L.; Yu, Y.; Hu, R.; Lutz, C.J.; Taffet, S.M.; Jalife, J. Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation. J. Am. Coll. Cardiol., 2012, 60(18), 1799-1806.
[32]
He, X.; Gao, X.; Peng, L.; Wang, S.; Zhu, Y.; Ma, H.; Lin, J.; Duan, D.D. Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7. Circ. Res., 2011, 108(2), 164-175.
[33]
Li, J.; Yang, Y.; Ng, C.Y.; Zhang, Z.; Liu, T.; Li, G. Association of plasma transforming growth factor-ß1 levels and the risk of atrial fibrillation: a meta-analysis. PLoS One, 2016, 11(5), e0155275.
[34]
Rahmutula, D.; Marcus, G.M.; Wilson, E.E.; Ding, C.H.; Xiao, Y.; Paquet, A.C.; Barbeau, R.; Barczak, A.J.; Erle, D.J.; Olgin, J.E. Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1. Cardiovasc. Res., 2013, 99(4), 769-779.
[35]
Schneider, M.P.; Hua, T.A.; Böhm, M.; Wachtell, K.; Kjeldsen, S.E.; Schmieder, R.E. Prevention of atrial fibrillation by renin-angiotensin system inhibition a meta-analysis. J. Am. Coll. Cardiol., 2010, 55(21), 2299-2307.
[36]
Goette, A.; Schön, N.; Kirchhof, P.; Breithardt, G.; Fetsch, T.; Häusler, K.G.; Klein, H.U.; Steinbeck, G.; Wegscheider, K.; Meinertz, T. Angiotensin II-antagonist in paroxysmal atrial fibrillation (ANTIPAF) trial. Circ Arrhythm Electrophysiol, 2012, 5(1), 43-51.
[37]
January, C.T.; Wann, L.S.; Alpert, J.S.; Calkins, H.; Cigarroa, J.E.; Cleveland, J.C., Jr; Conti, J.B.; Ellinor, P.T.; Ezekowitz, M.D.; Field, M.E.; Murray, K.T.; Sacco, R.L.; Stevenson, W.G.; Tchou, P.J.; Tracy, C.M.; Yancy, C.W. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J. Am. Coll. Cardiol., 2014, 64(21), e1-e76.
[38]
Kirchhof, P.; Benussi, S.; Kotecha, D.; Ahlsson, A.; Atar, D.; Casadei, B.; Castella, M.; Diener, H.C.; Heidbuchel, H.; Hendriks, J.; Hindricks, G.; Manolis, A.S.; Oldgren, J.; Popescu, B.A.; Schotten, U.; Van Putte, B.; Vardas, P. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J., 2016, 37(38), 2893-2962.
[39]
On, Y.K.; Jeon, E.S.; Lee, S.Y.; Shin, D.H.; Choi, J.O.; Sung, J.; Kim, J.S.; Sung, K.; Park, P. Plasma transforming growth factor beta1 as a biochemical marker to predict the persistence of atrial fibrillation after the surgical maze procedure. J. Thorac. Cardiovasc. Surg., 2009, 137(6), 1515-1520.
[40]
Kostin, S.; Klein, G.; Szalay, Z.; Hein, S.; Bauer, E.P.; Schaper, J. Structural correlate of atrial fibrillation in human patients. Cardiovasc. Res., 2002, 54(2), 361-379.
[41]
Sackner-Bernstein, J.D. The myocardial matrix and the development and progression of ventricular remodeling. Curr. Cardiol. Rep., 2000, 2(2), 112-119.
[42]
Xu, J.; Cui, G.; Esmailian, F.; Plunkett, M.; Marelli, D.; Ardehali, A.; Odim, J.; Laks, H.; Sen, L. Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation. Circulation, 2004, 109(3), 363-368.
[43]
Liu, Y.; Xu, B.; Wu, N.; Xiang, Y.; Wu, L.; Zhang, M.; Wang, J.; Chen, X.; Li, Y.; Zhong, L. Association of MMPs and TIMPs with the occurrence of atrial fibrillation: a systematic review and meta-analysis. Can. J. Cardiol., 2016, 32(6), 803-813.
[44]
Huxley, R.R.; Lopez, F.L.; MacLehose, R.F.; Eckfeldt, J.H.; Couper, D.; Leiendecker-Foster, C.; Hoogeveen, R.C.; Chen, L.Y.; Soliman, E.Z.; Agarwal, S.K.; Alonso, A. Novel association between plasma matrix metalloproteinase-9 and risk of incident atrial fibrillation in a case-cohort study: The atherosclerosis risk in communities study. PLoS One, 2013, 8(3), e59052.
[45]
Sasaki, N.; Okumura, Y.; Watanabe, I.; Mano, H.; Nagashima, K.; Sonoda, K.; Kogawa, R.; Ohkubo, K.; Nakai, T.; Hirayama, A. Increased levels of inflammatory and extracellular matrix turnover biomarkers persist despite reverse atrial structural remodeling during the first year after atrial fibrillation ablation. J. Interv. Card. Electrophysiol., 2014, 39(3), 241-249.
[46]
Hijazi, Z.; Oldgren, J.; Siegbahn, A.; Granger, C.B.; Wallentin, L. Biomarkers in atrial fibrillation: A clinical review. Eur. Heart J., 2013, 34(20), 1475-1480.
[47]
Wazni, O.M.; Martin, D.O.; Marrouche, N.F.; Latif, A.A.; Ziada, K.; Shaaraoui, M.; Almahameed, S.; Schweikert, R.A.; Saliba, W.I.; Gillinov, A.M.; Tang, W.H.; Mills, R.M.; Francis, G.S.; Young, J.B.; Natale, A. Plasma B-type natriuretic peptide levels predict postoperative atrial fibrillation in patients undergoing cardiac surgery. Circulation, 2004, 110(2), 124-127.
[48]
Gibson, P.H.; Croal, B.L.; Cuthbertson, B.H.; Rae, D.; McNeilly, J.D.; Gibson, G.; Jeffrey, R.R.; Buchan, K.G.; El-Shafei, H.; Hillis, G.S. Use of preoperative natriuretic peptides and echocardiographic parameters in predicting new-onset atrial fibrillation after coronary artery bypass grafting: a prospective comparative study. Am. Heart J., 2009, 158(2), 244-251.
[49]
Sezai, A.; Hata, M.; Niino, T.; Kasamaki, Y.; Nakai, T.; Hirayama, A.; Minami, K. Study of the factors related to atrial fibrillation after coronary artery bypass grafting: a search for a marker to predict the occurrence of atrial fibrillation before surgical intervention. J. Thorac. Cardiovasc. Surg., 2009, 137(4), 895-900.
[50]
Tavakol, M.; Hassan, K.Z.; Abdula, R.K.; Briggs, W.; Oribabor, C.E.; Tortolani, A.J.; Sacchi, T.J.; Lee, L.Y.; Heitner, J.F. Utility of brain natriuretic peptide as a predictor of atrial fibrillation after cardiac operations. Ann. Thorac. Surg., 2009, 88(3), 802-807.
[51]
Gasparovic, H.; Burcar, I.; Kopjar, T.; Vojkovic, J.; Gabelica, R.; Biocina, B.; Jelic, I. NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery. Eur. J. Cardiothorac. Surg., 2010, 37(1), 100-105.
[52]
Masson, S.; Wu, J.H.; Simon, C.; Barlera, S.; Marchioli, R.; Mariani, J.; Macchia, A.; Lombardi, F.; Vago, T.; Aleksova, A.; Dreas, L.; Favaloro, R.R.; Hershson, A.R.; Puskas, J.D.; Dozza, L.; Silletta, M.G.; Tognoni, G.; Mozaffarian, D.; Latini, R. Circulating cardiac biomarkers and postoperative atrial fibrillation in the OPERA trial. Eur. J. Clin. Invest., 2015, 45(2), 170-178.
[53]
Anatoĺevna, R.O.; Veniaminovich, F.O.; Mikhaylovich, K.S. Predictors of new-onset atrial fibrillation in elderly patients with coronary artery disease after coronary artery bypass graft. J. Geriatr. Cardiol., 2016, 13(5), 444-449.
[54]
Ata, Y.; Turk, T.; Ay, D.; Eris, C.; Demir, M.; Ari, H.; Ata, F.; Yavuz, S.; Ozyazicioglu, A. Ability of B-type natriuretic peptide in predicting postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. Heart Surg. Forum, 2009, 12(4), E211-E216.
[55]
Cai, G.L.; Chen, J.; Hu, C.B.; Yan, M.L.; Xu, Q.H.; Yan, J. Value of plasma brain natriuretic peptide levels for predicting postoperative atrial fibrillation: a systemic review and meta-analysis. World J. Surg., 2014, 38(1), 51-59.
[56]
Rossi, A.; Enriquez-Sarano, M.; Burnett, J.C., Jr; Lerman, A.; Abel, M.D.; Seward, J.B. Natriuretic peptide levels in atrial fibrillation: a prospective hormonal and Doppler-echocardiographic study. J. Am. Coll. Cardiol., 2000, 35(5), 1256-1262.
[57]
Costello-Boerrigter, L.C.; Boerrigter, G.; Redfield, M.M.; Rodeheffer, R.J.; Urban, L.H.; Mahoney, D.W.; Jacobsen, S.J.; Heublein, D.M.; Burnett, J.C. Jr Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: Determinants and detection of left ventricular dysfunction. J. Am. Coll. Cardiol., 2006, 47(2), 345-353.
[58]
Bruins, P.; te Velthuis, H.; Yazdanbakhsh, A.P.; Jansen, P.G.; van Hardevelt, F.W.; de Beaumont, E.M.; Wildevuur, C.R.; Eijsman, L.; Trouwborst, A.; Hack, C.E. Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia. Circulation, 1997, 96(10), 3542-3548.
[59]
Aviles, R.J.; Martin, D.O.; Apperson-Hansen, C.; Houghtaling, P.L.; Rautaharju, P.; Kronmal, R.A.; Tracy, R.P.; Van Wagoner, D.R.; Psaty, B.M.; Lauer, M.S.; Chung, M.K. Inflammation as a risk factor for atrial fibrillation. Circulation, 2003, 108(24), 3006-3010.
[60]
Worden, J.C.; Asare, K. Postoperative atrial fibrillation: role of inflammatory biomarkers and use of colchicine for its prevention. Pharmacotherapy, 2014, 34(11), 1167-1173.
[61]
Lo, B.; Fijnheer, R.; Nierich, A.P.; Bruins, P.; Kalkman, C.J. C-reactive protein is a risk indicator for atrial fibrillation after myocardial revascularization. Ann. Thorac. Surg., 2005, 79(5), 1530-1535.
[62]
Paschalis, A.; Tousoulis, D.; Demosthenous, M.; Antonopoulos, A.; Papaioannou, S.; Miliou, A.; Koumallos, N.; Antoniades, C.; Stefanadis, C. Pre-operative inflammation and post-operative atrial fibrillation in coronary artery bypass surgery. Int. J. Cardiol., 2014, 173(2), 327-328.
[63]
Henn, V.; Slupsky, J.R.; Gräfe, M.; Anagnostopoulos, I.; Förster, R.; Müller-Berghaus, G.; Kroczek, R.A. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature, 1998, 391(6667), 591-594.
[64]
Kim, Y.M.; Kattach, H.; Ratnatunga, C.; Pillai, R.; Channon, K.M.; Casadei, B. Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery. J. Am. Coll. Cardiol., 2008, 51(1), 68-74.
[65]
Clermont, G.; Vergely, C.; Jazayeri, S.; Lahet, J.J.; Goudeau, J.J.; Lecour, S.; David, M.; Rochette, L.; Girard, C. Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass. Anesthesiology, 2002, 96(1), 80-87.
[66]
Levy, J.H.; Tanaka, K.A. Inflammatory response to cardiopulmonary bypass. Ann. Thorac. Surg., 2003, 75(2), S715-S720.
[67]
Antoniades, C.; Van-Assche, T.; Shirodaria, C.; Diesch, J.; Antonopoulos, A.S.; Lee, J.; Cunnington, C.; Tousoulis, D.; Stefanadis, C.; Casadei, B.; Taggart, D.; Channon, K.M.; Leeson, P. Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery. Circulation, 2009, 120(11)(Suppl.), S170-S176.
[68]
Thygesen, K.; Alpert, J.S.; Jaffe, A.S.; Simoons, M.L.; Chaitman, B.R.; White, H.D. Third universal definition of myocardial infarction. Nat. Rev. Cardiol., 2012, 9(11), 620-633.
[69]
Moreno, V.; Hernández-Romero, D.; Vilchez, J.A.; García-Honrubia, A.; Cambronero, F.; Casas, T.; González, J.; Martínez, P.; Climent, V.; de la Morena, G.; Valdés, M.; Marín, F. Serum levels of high-sensitivity troponin T: A novel marker for cardiac remodeling in hypertrophic cardiomyopathy. J. Card. Fail., 2010, 16(12), 950-956.
[70]
Hudson, M.P.; O’Connor, C.M.; Gattis, W.A.; Tasissa, G.; Hasselblad, V.; Holleman, C.M.; Gaulden, L.H.; Sedor, F.; Ohman, E.M. Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis. Am. Heart J., 2004, 147(3), 546-552.
[71]
Korley, F.K.; Jaffe, A.S. Preparing the United States for high-sensitivity cardiac troponin assays. J. Am. Coll. Cardiol., 2013, 61(17), 1753-1758.
[72]
Latini, R.; Masson, S.; Pirelli, S.; Barlera, S.; Pulitano, G.; Carbonieri, E.; Gulizia, M.; Vago, T.; Favero, C.; Zdunek, D.; Struck, J.; Staszewsky, L.; Maggioni, A.P.; Franzosi, M.G.; Disertori, M. Circulating cardiovascular biomarkers in recurrent atrial fibrillation: Data from the GISSI-atrial fibrillation trial. J. Intern. Med., 2011, 269(2), 160-171.
[73]
Januzzi, J.L., Jr Troponin testing after cardiac surgery. HSR Proc. Intensive Care Cardiovasc. Anesth., 2009, 1(3), 22-32.
[74]
Knayzer, B.; Abramov, D.; Natalia, B.; Tovbin, D.; Ganiel, A.; Katz, A. Atrial fibrillation and plasma troponin I elevation after cardiac surgery: relation to inflammation-associated parameters. J. Card. Surg., 2007, 22(2), 117-123.
[75]
Hernández-Romero, D.; Vílchez, J.A.; Lahoz, Á.; Romero-Aniorte, A.I.; Orenes-Piñero, E.; Caballero, L.; Jara-Rubio, R.; Arribas, J.M.; García-Alberola, A.; Valdés, M.; Lip, G.Y.; Marín, F. High-sensitivity troponin T as a biomarker for the development of atrial fibrillation after cardiac surgery. Eur. J. Cardiothorac. Surg., 2014, 45(4), 733-738.


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VOLUME: 26
ISSUE: 5
Year: 2019
Page: [916 - 924]
Pages: 9
DOI: 10.2174/0929867324666170727104930
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