Tuftsin – Properties and Analogs (E-pub Ahead of Print)
Agnieszka Siebert ,
Monika Gensicka-Kowalewska ,
Grzegorz Cholewiński ,
Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation or suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism to infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). Tuftsin is an endogenous immunomodulator of a wide spectrum of biological activity. Tetrapeptide 3 provides also antitumor, antimicrobial, anticoagulant and analgesic properties. In this paper, we presented tuftsin derivatives described over the years, its biological activity and potential clinical applications.
Keywords: Tuftsin, immunomodulator, biological activity, Selank, tuftsin analogs, regulatory peptides.
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