Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


Tuftsin – Properties and Analogs

(E-pub Ahead of Print)

Author(s): Agnieszka Siebert , Monika Gensicka-Kowalewska , Grzegorz Cholewiński , Krystyna Dzierzbicka.


Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation or suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism to infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). Tuftsin is an endogenous immunomodulator of a wide spectrum of biological activity. Tetrapeptide 3 provides also antitumor, antimicrobial, anticoagulant and analgesic properties. In this paper, we presented tuftsin derivatives described over the years, its biological activity and potential clinical applications.

Keywords: Tuftsin, immunomodulator, biological activity, Selank, tuftsin analogs, regulatory peptides.

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Article Details

Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/0929867324666170725140826
Price: $95