Background: Heterocyclic compounds are the main class of medicinally
important compounds. Many heterocyclic compounds bearing a five-membered ring
in their structure have a good spectrum of biological activities. Thiazole is an important
class of five-membered heterocyclic compounds. Thiazole and its derivatives
exhibited a broad range of biological activities due to the presence of various reaction
posseses. Thiazole, heterocyclic nucleus is present in several potent pharmacologically
active molecules such as Sulfathiazole (antimicrobial drug), Ritonavir (antiretroviral
drug), Tiazofurin (antineoplastic drug) and Abafungin (antifungal drug)
etc. The search for some novel biologically active thiazoles is to be continued in the
field of medicinal chemistry for investigators. An aim of this review is to identify
and try making a SAR (Structure Activity Relationship) of substituted thiazole nucleus
as possible new antimalarials.
Method: Author undertook a structured search of bibliographic databases for peerreviewed
research literature using a focused review question and inclusion/exclusion
criteria. The quality of retrieved papers was appraised using standard tools. The
characteristics of screened papers were described, and a deductive qualitative content
analysis methodology was applied to analyse the interventions and findings of included
studies using a conceptual framework.
Result: Fifteen papers were included in the review; the majority were described
about many biological activity of thiazole nucleus. Seven papers were find that had
impacted upon the thaizoles as antimalarials. Some papers focused on the design,
synthesis and antimalarial activity evaluation of thiazole derivatives. This review
identified and made a SAR (Structure Activity Relationship) of substituted thiazole
nucleus as possible new antimalarials.
Conclusion: This review describes ongoing research in the search for novel thiazoles
as targets and new antimalarial drug molecules.