Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Pro-angiogenic Molecules for Therapeutic Angiogenesis

(E-pub Ahead of Print)

Author(s): Selvaprithiviraj Vignesh , Sankar Deepthi , Amirthalingam Sivashanmugam, Sowmya Srinivasan , Rangasamy Jayakumar.

Abstract:

Angiogenesis, the formation of new functional blood vessels from the preexisting vasculature, is a highly orchestrated event, tightly controlled by a convoluted combination of biochemical and biomolecular signals. Therapeutic angiogenesis is a clinical approach to trigger neovascularization, which requires balance of multiple proangiogenic factors. It is of prime importance as it augments neovascularization, thereby enhancing tissue oxygen exchange which is crucial to several ischemia related pathophysiological conditions. Direct delivery of angiogenic growth factors, or agonists which stimulate tissues to release growth factors have been traditionally employed to stimulate neovascularization. In this review, we discuss the role of pro-angiogenic molecules such as growth factors, peptides for inducing therapeutic angiogenesis. Additionally, the review updates recent applications of new small molecules, inorganic nanomaterials & polysaccharides in promoting angiogenesis.

Keywords: Angiogenesis, pro-angiogenic molecules, growth factors, peptides, small molecules, inorganic nanoparticles, polysaccharides.

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Article Details

VOLUME: 24
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/0929867324666170724142641
Price: $95