Background: Recently sustainable transformations are a challenge for the researchers in areas
like health, social sector and environment. To overcome these troubles, it has been planned to produce
simple and facile methods to carry organic reaction under mild & eco-friendly conditions. Nano
magnetite supported catalysis is a very significant and growing field in catalytic science with application
in organic synthesis. Therefore, this research article focuses on the synthesis of nano-magnetite
supported cysteine organocatalyst and its application in catalysis and synthetic organic chemistry.
Methods: Magnetically recyclable heterogeneous catalyst ferrite-L-cysteine was prepared by simple
stirring method in distilled water media without any other reagent followed by dehydration technique.
The synthesized catalyst is well characterized by FT-IR, TEM and FEG-SEM-EDS spectroscopy. This
functionalised nanocat- Fe-cys was employed in the synthesis of quinolines under Friedlander reaction
and also pyrazole derivative under Knoevenagel condensation reaction. The % conversion of products
was checked by thin layer chromatography and the synthesized compounds were further confirmed by
Results: To check the competency of synthesized nanocat-Fe-cys for Friedlander & Knoevenagel raction
under solvent free conditions, microwave irradiation method employed superiorly over conventional
oil bath method. The products were obtained in very clean & noticeably higher yield (81-94%). The
catalyst ferrite cysteine was found to be recyclable for ten consecutive run with no significant loss in
Conclusion: In the present research article, the synthesis of highly active, recyclable & versatile organo
nanocatlyst ferrite-cysteine using easily available precursor via the simple impregnation procedure is
presented. The MNPs was found to be stable under investigated conditions & highly effective in the
synthesis of substituted quinolines and pyrazole derivatives. The simple eco-friendly method, mild reaction
conditions, economically affordable and good product yields make it an attractive sustainable protocol.