Introduction: Phenotypic characterization of COPD subjects may rely on clinical and
physiological manifestations, imaging, assessment of patient-related outcomes (health related quality
of life), COPD comorbidities, COPD exacerbations and systemic inflammation. The aim of the study
was to evaluate and to analyze the health-related quality of life (HRQL) in COPD patients classified
into different phenotypes.
Methods: 395 consecutive COPD patients were enrolled into the study. Spirometric data were analyzed
(FEV1, FVC, FEV1/FVC). HRQL was assessed by the St. George Respiratory Questionnaire
(SGRQ), COPD Assessment Test (CAT) and Clinical COPD Questionnaire (CCQ).
Results: The cohort consisted of 395 COPD patients with mean age 62.7 ± 9.4 years, 79 % were
males. Patients were divided in 4 groups according to phenotypes: 44% of the patients were nonexacerbators,
35% frequent exacerbators with chronic bronchitis (CB), 12% frequent exacerbators
without CB, and 8% were patients with asthma-COPD overlap syndrome (ACOS). There were
statistically significant differences in HRQL and lung function between COPD phenotypes. Frequent
exacerbators with chronic CB and without CB had the similar total SGRQ scores, CCQ scores and
CAT, and these scores were worse in comparison with HRQL of non-exacerbators and patients with
Conclusion: Frequent exacerbators with chronic CB and without CB have a more severe deterioration
of the HRQL and worse lung function then non-exacerbators and patients with ACOS.