Background: Prostate cancer is the second most prevailing cancer among men worldwide.
In the most cases, prostate cancer is slowly progressing, whereas, in some cases, it is a rapidly
progressing disease leading to the significantly high mortality rate. Thus, there is still demand
for prostate-specific imaging in order to provide image-guided early diagnosis and for the provision
of patient-specific therapy.
Discussion: Besides discussing traditional diagnostic approaches, this review illustrates a perspective
on prostate cancer imaging summarizing current imaging approaches with a special focus on
Prostate Specific Membrane Antigen (PSMA), Bombesin (BN) and Androgen Receptor (AR) targeted
imaging using Positron Emission Tomography (PET) and Single Positron Emission Computed
Tomography (SPECT) based on 99mTc and other radiotracers. Here, the prostate biology is
reconsidered for nuclear imaging as future modality for early, rapid and efficient diagnosis of prostate
Conclusion: Future direction in prostate cancer imaging involves the development of androgen receptor
based imaging using nonsteroidal antiandrogen agent for early diagnosis of prostate cancer.