Current Organic Chemistry

Atta-ur-Rahman , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Chemistry and Applications of 4-Hydroxyquinolin-2-one and Quinoline-2,4-dione– Based Compounds

(E-pub Ahead of Print)

Author(s): Karel Proisl, Stanislav Kafka, Janez Košmrlj.

Abstract:

4-Hydroxyquinolin-2-ones and quinoline-2,4-diones, a subset of the quinolone scaffold, have attracted attention due to their biological properties. These structures are present in many classes of natural products and pharmaceutical agents and show promise in antiviral and antibacterial treatment. They possess anticonvulsive effects, selective affinity to cannabinoid receptors, and other interesting biological activity. Some of these compounds have the potential for protection and properties modification of natural as well as synthetic materials as antioxidants, antidegradants, antifungal agents, UV absorbers, optical brighteners, luminophores, etc. The importance of these compounds stimulated development of innovative conventional and modern catalytic methods for their preparation. The present review highlights recent progress in the above subjects.

Keywords: 4-hydroxyquinolin-2-one; quinoline-2, 4-dione; organic synthesis; biological activity; applications

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Article Details

VOLUME: 21
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1385272821666170711155631
Price: $95