Background: Pyrrole moiety is found in naturally occurring compounds such as chlorophyll,
haem, and vitamin B12 and present in a number of drugs for example atorvastatin, ketorolac,
elopiprazole, tolmetin and sunitinib. Various methods have been used for the synthesis of pyrrole derivatives;
however, still there is a need for environmentally benign and economic protocol.
Method: We have reported a simple, mild and speedy synthesis of N-substituted 2,5-dimethyl pyrrole
derivatives in ‘’GAAS’’ as medium and catalyst at room temperature and under ultrasound irradiation.
Results: This protocol was employed for the synthesis of various 2,5-dimethyl-N-substituted pyrrolederivatives
using both aliphatic as well as aromatic amines in short time (2 to 10 minutes)with excellent
yield (84-95%) at room temperature and under ultrasonic irradiation. The catalytic system
“GAAS’’ was regenerated and reused five times effectively without major loss of activity.
Conclusion: In conclusion, we have developed an eco-friendly, simple, faster, reusable, mild, and efficient
protocol for the synthesis of N-substituted pyrrole derivatives. This bio-based protocol is cost-effective and
greener methodology for the synthesis of biologically active N-substituted pyrrole derivatives.