Alzheimer's disease (AD) is a devastating neurological illness with a heavy economic impact. Further
comorbidities in combination with the social impact of this disorder increase the urgency of a clearer comprehension
of its etiopathogenesis, allowing the execution of novel therapeutic strategies. Despite astrocytes have been
widely described as active participant in the regulation of cerebral circuits, available data are still poor. Even less
information is available about their precise role in the pathogenesis of illness. Moreover, the scant knowledge
about the astrocyte-neuron interplay in health and disease still impedes pioneering discoveries.
The focus of this review is to look for new and innovative pharmacological approaches against AD. In order to
perform this, we used the following keywords in PubMed search engine: astrocytes, therapy, Alzheimer's disease,
and glia in different combinations.
With this review, we collected data available in literature describing how also astrocytes besides neurons might
be new potential targets for drug discovery. Different approaches currently being studied include modulation of
glutamate transporters expression, astroglial genetic manipulation, free radicals inhibition, up-regulation of neurotrophins,
and regulation of astrogliosis and neuroinflammation.
Since several studies already demonstrated that astrocytes are definitely involved in AD pathogenesis, these cells
can represent a promising new therapeutic target.