Frontiers in Drug Discovery

Volume: 2

The Search for Antidepressants - An Integrative View of Drug Discovery

Editor(s): Andre F. Carvalho, Gislaine Z. Reus and João Quevedo

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Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. ...
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The Search For Novel Antidepressants  promotion: free to download

Pp. i

Andre F. Carvalho, Gislaine Z. Réus and João Quevedo



Preface  promotion: free to download

Pp. ii

Andre F. Carvalho, Gislaine Z. Réus and João Quevedo



List of Contributors  promotion: free to download

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Andre F. Carvalho, Gislaine Z. Reus and João Quevedo



Innovative Solutions to the Development of Novel Antidepressants

Pp. 1-40 (40)

Daniela Felice, Alain M. Gardier, Connie Sanchez and Denis J. David


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Animal Models of Depression: Current Status and Perspectives

Pp. 41-76 (36)

Morgana Moretti, Manuela P. Kaster and Ana Lúcia S. Rodrigues


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Potential Role of Optogenetics for The Development of Novel Antidepressants

Pp. 77-98 (22)

T. Chase Francis and Mary Kay Lobo


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Monoamine Oxidase-A: A Valid Target for the Management of Depression

Pp. 126-134 (9)

Bijo Mathew and Jerad Suresh


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Repurposed Drugs: A Shortcut to the Discovery of Novel Antidepressants?

Pp. 135-176 (42)

Young Sup Woo, Yena Lee and Roger S. McIntyre


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Ketamine and Glutamatergic Compounds: Exploring Biomarkers and Mechanisms Related to Rapid Antidepressant Action

Pp. 177-200 (24)

Gislaine Z. Réus, Helena M. Abelaira, Gerard Sanacora and João Quevedo


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Novel Antidepressant Targets for Cognitive Dysfunction in Major Depressive Disorder

Pp. 201-221 (21)

Beatrice Bortolato and Andre F. Carvalho


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Novel Non-Monoaminergic Antidepressants: Focus on Neuropeptides

Pp. 242-255 (14)

Donatella Marazziti, Federico Mucci, Stefano Baroni and Liliana Dell`Osso


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Novel Antidepressant Drugs: Exploring Neurotrophins and Intracellular Signaling Pathways

Pp. 256-297 (42)

Gianluca Serafini, Admena Rreshketa, Maurizio Pompili, Paolo Girardi, Goutam Brahmachari and Mario Amore


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Shared Pathophysiology between Depression, Obesity and Metabolic Disturbances: Novel Antidepressant Targets?

Pp. 298-356 (59)

Léa Décarie-Spain, Dominique Matthys and Stephanie E. Fulton


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Subject Index  promotion: free to download

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Andre F. Carvalho, Gislaine Z. Reus and João Quevedo