Circadian MicroRNAs in Cardioprotection

Author(s): Yoshimasa Oyama, Colleen Marie Bartman, Jennifer Gile, Tobias Eckle*.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 25 , 2017

Become EABM
Become Reviewer

Abstract:

The most dramatic feature of life on Earth is our adaptation to the cycle of day and night. Throughout evolutionary time, almost all living organisms developed a molecular clock linked to the light-dark cycles of the sun. In present time, we know that this molecular clock is crucial to maintain metabolic and physiological homeostasis. Indeed, a dysregulated molecular clockwork is a major contributing factor to many metabolic diseases. In fact, the time of onset of acute myocardial infarction exhibits a circadian periodicity and recent studies have found that the light regulated circadian rhythm protein Period 2 (PER2) elicits endogenous cardioprotection from ischemia. Manipulating the molecular clockwork may prove beneficial during myocardial ischemia in humans. MicroRNAs are small non-coding RNA molecules capable of silencing messenger RNA (mRNA) targets. MicroRNA dysregulation has been linked to cancer development, cardiovascular and neurological diseases, lipid metabolism, and impaired immunity. Therefore, microRNAs are gaining interest as putative novel disease biomarkers and therapeutic targets. To identify circadian microRNA-based cardioprotective pathways, a recent study evaluated transcriptional changes of PER2 dependent microRNAs during myocardial ischemia. Out of 352 most abundantly expressed microRNAs, miR-21 was amongst the top PER2 dependent microRNAs and was shown to mediate PER2 elicited cardioprotection. Further analysis suggested circadian entrainment via intense light therapy to be a potential strategy to enhance miR-21 activity in humans. In this review, we will focus on circadian microRNAs in the context of cardioprotection and will highlight new discoveries, which could lead to novel therapeutic concepts to treat myocardial ischemia.

Keywords: PER2, miR-21, circadian, clock, heart, ischemia, intense light, metabolism.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 23
ISSUE: 25
Year: 2017
Page: [3723 - 3730]
Pages: 8
DOI: 10.2174/1381612823666170707165319
Price: $58

Article Metrics

PDF: 20
HTML: 1