Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism

Author(s): Jahangir Iqbal*, Ali Al Qarni, Abbas Hawwari, Ahmad F. Alghanem, Gasmelseed Ahmed.

Journal Name: Current Diabetes Reviews

Volume 14 , Issue 5 , 2018

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Abstract:

Background: Metabolic syndrome is associated with increased risk for both type 2 diabetes and cardiovascular disease. Development of these pathologies is associated with the disorders of lipid and lipoprotein metabolism. Dyslipidemia leads to the overproduction of potentially atherogenic lipid and lipoproteins. Furthermore, there is a decrease in the levels of high-density lipoproteins and an increase in the levels of remnant and small dense LDL particles.

Conclusion: In the current review, we have discussed the pathophysiology of lipoprotein biosynthesis and metabolism in the metabolic syndrome. Finally, we describe regulation of lipoprotein metabolism which may be used as a potential target for treating dyslipidemia in metabolic syndrome.

Keywords: Metabolic syndrome, dyslipidemia, insulin resistance, lipid metabolism, lipoprotein biosynthesis, microRNA.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2018
Page: [427 - 433]
Pages: 7
DOI: 10.2174/1573399813666170705161039
Price: $58

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