Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

Author(s): Paramjit S. Tappia*, Adriana Adameova, Naranjan S. Dhalla.

Journal Name: Current Medicinal Chemistry

Volume 25 , Issue 3 , 2018

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Abstract:

Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications.

Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions.

Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.

Keywords: Sulphur-containing amino acids, Taurine, Cysteine, Diabetes mellitus, Diabetic cardiomyopathy, Preventive nutrition.

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Article Details

VOLUME: 25
ISSUE: 3
Year: 2018
Page: [336 - 345]
Pages: 10
DOI: 10.2174/0929867324666170705115207
Price: $58

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