Background: Patients with diabetes mellitus have an increased risk of mortality
due to cardiovascular complications. Supplementation with specific sulphur-containing
amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes
and associated cardiovascular complications.
Observations: It is well-known that oxidative stress plays an important role in the pathogenesis
of diabetes-induced cardiovascular disease, which is invariably associated with
abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome.
Cysteine and taurine are among the most common sulphur-containing amino acids
and their cellular levels decline during diabetes that may contribute to the development of
the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular
and subcellular functions in the heart, they also exhibit antioxidant properties and thus
may exert beneficial effects in different pathophysiological conditions.
Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may
serve as an important mechanism for the attenuation of diabetes-induced subcellular and
functional abnormalities in the heart.
Keywords: Sulphur-containing amino acids, Taurine, Cysteine, Diabetes mellitus, Diabetic cardiomyopathy, Preventive
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