Editorial: Research and Selection of Multitarget Compounds in Medicinal Chemistry | BenthamScience


Editorial: Research and Selection of Multitarget Compounds in Medicinal Chemistry

Author(s): Luciana Scotti, Francisco Jaime Bezerra Mendonça, Marcus T. Scotti.

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 16 , 2017

Abstract:

In drug discovery, a hit series, with the desired primary and secondary activities, as well as physiochemical properties is identified such that the final agent will be useful when administered to real patients [1]. Medicinal chemistry can improve recognition and the binding geometries (pharmacophores) of candidate compounds, and their target’s affinity. Medicinal chemistry, in a modern view, is dedicated to understanding molecular mechanisms, chemical relationships, and the pharmacological activities involved in drug action thru pharmacodynamic and pharmacokinetic factors. The introduction of new technologies has become a prime concept in medicinal chemistry, expanding its interdisciplinary character. Most drugs are small bioactive molecules that interact with specific macromolecules or receptors, resulting in therapeutic effects. Modern computational methods determine...

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 24
ISSUE: 16
Year: 2017
Page: [1627 - 1628]
Pages: 2
DOI: 10.2174/092986732416170704114736

Article Metrics

PDF: 23