Background: Phagocytosis is regarded to be impaired in HIV-1 infected adults, leading
to high frequency and severity of several infections in this population. Data is contradictory with regards
to individual facets in HIV infection.
Objective: Aim of this study was to assess the phagocytic activity during the natural course of HIV
Method: It is a longitudinal study assessing natural course and impairment of neutrophil and monocyte
phagocytosis in both naïve and HAART treated patients.
Results: A lower neutrophil phagocytic activity was recorded in naïve patients compared to treated
patients. Interestingly, a downward trend of neutrophil phagocytic activity was recorded in both
groups, irrespectively of HAART intake, within 48 weeks of observation.
Conclusion: Defects of innate immunity appear to be present in HIV infected patients regarding
phagocytic activity of monocytes and of neutrophils which seems to decline over time. These deficiencies
are influenced by the levels of CD4 cell counts and viral load.
Keywords: Highly active antiretroviral therapy, HIV infection, Immune deficiency, phagocytosis, microbial, macrophages,
monocytes, neutrophils, dendritic cells, innate immunity, oxidative burst.
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