Background: Pyrazoline scaffold is a key structural motif found among pharmaceutically
active molecules including synthetic and natural products. The molecules with pyrazoline
backbone from natural as well as synthetic origin are investigated worldwide for the development of
efficient and potent drugs. Over the past few years, pyrazoline derivatives are used for the treatment
of diverse dreadful diseases including malaria, cardiovascular, tumor, HIV, diabetes, tuberculosis,
infections, inflammation, etc.
Objective: The main objective of this review article is to emphasize on the recent efforts of researchers
to study and understand the pharmacological aspects of various pyrazolines and their
analogues derived from chalcone derivatives.
Methods: A well known synthetic method for the preparation of pyrazolines is the ring closure reaction
of α, β unsaturated ketones with nitrogen based nucleophiles like hydrazine and its derivatives.
The synthetic manipulations of pyrazoline derivatives offer a high degree of varied medicinal properties
with improved potency and good pharmacological actions.
Results: The present review compiles the different synthetic methods to arrive at diversely
substituted pyrazoline derivatives. It presents the biological evaluations such as, antimicrobial, antioxidant,
antidepressant, antimalarial, analgesic, anti-inflammatory, antiviral, antidiabetic, antitubercular,
anticancer and anticonvulsant properties and also documents the utility of these compounds based on
Conclusion: This review presents that the synthetic pyrazolines are excellent scaffolds which possess
multiple biological and medicinal properties.