Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets

Author(s): Maria Elizbeth Alvarez-Sanchez, Jose Luis Villalpando, Laura Itzel Quintas-Granados, Rossana Arroyo*.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 23 , 2017


Abstract:

Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans.

Keywords: Hypusination machinery, ornithine decarboxylase (ODC), polyamines, polyamine oxidase (PAO), putrescine, spermine, spermidine, Trichomonas vaginalis.

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Article Details

VOLUME: 23
ISSUE: 23
Year: 2017
Page: [3359 - 3366]
Pages: 8
DOI: 10.2174/1381612823666170703162754
Price: $58

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