Cyclic dipeptides are the simplest peptide derivatives commonly found in nature.
These chiral molecules are easily synthesized from readily available α-amino acids using a
simple methodology. They are privileged structures with the ability to bind to a wide range of
receptors and have a broad variety of biological and pharmacological activities. We will give
a brief overview of their status giving and interesting reference list about the last works.
Keywords: Cyclic dipeptides, Secondary metabolites, Biological activities, diketopiperazines, cyclo(L-pro), natural
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