Zein-based Nanocarriers as Potential Natural Alternatives for Drug and Gene Delivery: Focus on Cancer Therapy

Author(s): Ahmed Elzoghby*, May Freag*, Hadeer Mamdouh, Kadria Elkhodairy.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 35 , 2017

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Abstract:

Protein nanocarriers possess unique merits including minimal cytotoxicity, numerous renewable sources, and high drug-binding capability. In opposition to delivery carriers utilizing hydrophilic animal proteins, hydrophobic plant proteins (e.g, zein) have great tendency in fabricating controlled-release particulate carriers without additional chemical modification to stiffen them, which in turn evades the use of toxic chemical crosslinkers. Moreover, zein is related to a class of alcohol-soluble prolamins and generally recognized as safe (GRAS) carrier for drug delivery. Various techniques have been adopted to fabricate zein-based nanoparticulate systems including phase separation coacervation, spray-drying, supercritical anti-solvent approach, electrospinning and self-assembly. This manuscript reviews the recent advances in the zein-based colloidal nano-carrier systems such as nanospheres, nanocapsules, micelles and nanofibers with a special focus on their physicochemical characteristics and drug delivery applications.

Keywords: Zein nanoparticles, drug delivery, gene delivery, protein delivery, anti-tumor efficacy, nano-carrier.

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Article Details

VOLUME: 23
ISSUE: 35
Year: 2017
Page: [5261 - 5271]
Pages: 11
DOI: 10.2174/1381612823666170622111250
Price: $58

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