Single nucleotide polymorphisms (SNPs) in non-coding RNAs (ncRNA) molecules affect
gene and protein expression and generate genetic variability influencing the risk of tumor diseases.
HOTAIR locates at the heart of the cell memory gene program and represents a prototype of long non
coding RNA (LncRNA) due to its capacity to regulate in-trans a distant chromosome landscape.
Aberrant expression of HOTAIR is frequently associated with pathogenesis and mostly with metastatic
progression of several human cancers. Different polymorphisms, particularly present in intronic
sequences, as well as in promoter regions of HOTAIR, are often associated with its aberrant expression,
patient prognosis, and cancer susceptibility in different tumor phenotypes.
In this minireview, we have summarized the main SNPs in HOTAIR sequence and their relation with
cancer risk in several types of solid tumors.