Experiences with 99mTc-HMPAO in a Diagnostic Pathway for Violent Patients with Schizophrenic Spectrum Disorders

Author(s): Morten Jacobsen*, Arvid Jensen, Guttorm Breivik Storvestre, Tone Marie Bergstrom, Diyar Nori Mohamad Rashi, Bjorn Nielssen, Pal Wiktor, Knut-Erik Hymer.

Journal Name: Current Radiopharmaceuticals

Volume 10 , Issue 2 , 2017

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Abstract:

Background and Objective: In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence.

Methods: Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence.

Results: All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings.

Conclusion: Traditionally, low accumulation of the tracer in SPECT is related to reduced perfusion of brain tissue. We discuss our findings in the light of other possible pathophysiological mechanisms.

Keywords: SPECT, Schizophrenia spectrum disorder, brain perfusion, violence, forensic psychiatry.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2017
Page: [115 - 122]
Pages: 8
DOI: 10.2174/1874471010666170621122221

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