Background: The impact of hyperfibrinogenemia on short-term outcomes after acute
ischemic stroke (AIS) is still not well understood.
Objective: We investigated the association between hyperfibrinogenemia upon hospital admission
and the short-term prognosis of AIS patients.
Methods: A total of 3,212 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals
in Suzhou city were included in the present study. Hyperfibrinogenemia was defined as having
a serum fibrinogen＞4.0g/L. Cox proportional hazard and logistic regression models were used to
estimate the effect of hyperfibrinogenemia on all-cause in-hospital mortality and poor discharge
outcome (modified Rankin Scale score≥3) in AIS patients.
Results: During hospitalization, 106 patients (3.3%) died from all-cause and 1226 (38.2%) patients
experienced poor functional outcome at discharge. Multivariable model adjusted for age, sex, baseline
National Institutes of Health Stroke Scale score, white blood cell count and other covariates,
showed that hyperfibrinogenemia was associated with a 1.76-fold increase in the risk of in-hospital
mortality (hazard ratio [HR] 1.76; 95% confidence interval [CI], 1.10–2.81; P-value=0.019).
However, there was no significant association between hyperfibrinogenemia and poor outcome
at discharge (adjusted odds ratios[OR]1.15; 95% CI 0.86–1.53; P-value=0.338). Sensitivity
and subgroup analyses also confirmed a significant association between hyperfibrinogenemia and
Conclusion: In patients with AIS, hyperfibrinogenemia at the time of admission was independently
associated with increased in-hospital mortality.