Background: Poly (butylene succinate) (PBS) is a biodegradable polyester synthesized
from succinic acid (SA) and 1,4 butanediol (BD). SA is derived from renewable resources and several
chemicals can be produced from it, such as BD. Poly (vinyl acetate) (PVAc) also attracts attention in
pharmaceutical applications. The development of copolymers of PBS and PVAc and entrapment of
drugs can thus result in relevant drug delivery system (DDS) with improved properties for
Objective: This work presents a new copolymer based on PBS and PVAc (PBS-g-PVAc). Ibuprofen
was entrapped into PBS-g-PVAc particles to be used as DDS.
Method: Polymerization of SA, maleic acid, and BD was performed in order to insert carbon double
bonds in PBS (uPBS). The unsaturation acts as the site for the grafting of PVAc, leading to the
formation of a reticulate PBS-g-PVAc copolymer. The intermediary and copolymer were
characterized by several techniques. PBS-g-PVAc had the swelling index evaluated for several
solvents. Ibuprofen was entrapped into PBS-g-PVAc particles and PBS-g-PVAc_Ibu system was
characterized, to determine ibuprofen entrapment and entrapment efficiency.
Results: The characterization supports the obtaining of PBS-g-PVAc. Ability to control the swelling
of the material was used to entrap ibuprofen. XRD and SEM support that ibuprofen was entrapped into
PBS-g-PVAc particles and high entrapment efficiency into PBS-g-PVAc particles was achieved.
Conclusion: Results allowed concluding that PBS-g-PVAc could be of great importance to the
entrapment of drugs that have limited use due to poor processability and/or bioavailability. The ease of
preparation could increase the efficiency and adherence to treatment.