β-Amino acids are being increasingly used in the design of bioactive ligands and more recently in the
generation of novel biomaterials. Peptides containing either individual β-amino acid substitutions or peptides
comprised entirely of β-amino acids, display unique properties in terms of their structural and/or chemical characteristics.
β-Peptides form well-defined secondary structures that exhibit different geometries compared to the
corresponding α-peptides. β-Peptides, including α-peptides containing only one or two β-amino acids, can be
easily modified with different functional groups and are metabolically stable and, together with the predictable
side chain topography, have led to the design of a growing number of bioactive β-peptides with a range of biological
targets and therapeutic applications. More recently, our understanding of the folding and self-assembly of
β-peptides has resulted in the generation of novel biomaterials. The focus of this review is to examine how the
structural and chemical properties of β-peptides have been exploited in the design of bioactive peptides and selfassembled
Keywords: β-Peptides, β-amino acids, peptidomimetic, bioactive ligand, proteolytic stability, self-assembly, biomaterials.
Rights & PermissionsPrintExport