Glycemic Variability and Insulin Needs in Patients with Type 1 Diabetes Mellitus Supplemented with Vitamin D: A Pilot Study Using Continuous Glucose Monitoring System

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Author(s): Karem Miléo Felício, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Thaís Pontes Arbage, Hana Andrade de Rider Brito, Amanda Soares Peixoto, Alana Ferreira de Oliveira, Fabricio de Souza Resende, Scarlatt Sousa Reis, Ana Regina Motta, Henrique da Costa Miranda, Luísa Corrêa Janaú, Elizabeth Sumi Yamada, João Soares Felício*.

Journal Name:Current Diabetes Reviews

Volume 13 , 2017

Abstract:

Background: Recent studies suggest that glycemic variability could influence the risk of complications in type 1 diabetes mellitus (T1DM). There are no data about the action of vitamin D (VD) on glycemic variability. Our pilot study aims to evaluate glycemic variability and insulin needs in patients with T1DM supplemented with VD.

Methods: 22 patients received doses of 4000 and 10000 IU/day of cholecalciferol for 12 weeks, according to the patient’s baseline VD levels and underwent continuous glucose monitoring system.

Results: Correlations were found between percentage variation (Δ) of glycemia standard deviation (ΔSDG), calculated using continuous glucose monitoring, with Δ of basal (r= 0.6; p <0.01) and total insulin dose (r= 0.6; p <0.01). Correlations between VD status after supplementation and Δ of prandial (r = 0.5; p <0.05) and total insulin dose (r = 0.4; p <0.05) were found, suggesting that the dose of insulin needed by patients is lower when VD status is better. We divided patients in two subgroups: SDG improved (subgroup 1; n =12 (55%)) and SDG worsened (subgroup 2; n =10 (45%)). Group 1, compared to subgroup 2, required a lower insulin dose (Δbasal insulin dose = -8.0 vs. 6.3%; p <0.05) and had a lower frequency of hypoglycemia (27% vs. 64%, hypoglycemias/days evaluated; p <0.01).

Conclusions: Our study suggests a relation between VD supplementation, improved glycemic variability, lower insulin needs and lower frequency of hypoglycemia in patients with T1DM.

Keywords: Type 1 Diabetes Mellitus, Vitamin D supplementation, Glycemic variability, Insulin resistance.

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Article Details

VOLUME: 13
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1573399813666170616075013
Price: $95