Albumin polymeric Nanoparticles (NPs) have opened a great expectancy as for controlled drug delivery
due to their therapeutic potency. Concomitantly biodegradable NPs technologies with target linked structures
to pave the way of personalised medicine are becoming increasingly important in sight of a therapeutically effective
research technology. This is particularly attractive for nanoparticle-based cancer delivery systems, based on
the known limitations and efforts to overcome. This new group of gamma irradiated-NPs inherited both the protein
delivery properties and robustness of polymer forming structures, and gamma irradiation techniques that
leave clean, innocuous and biodegradable NPs.
These protein NPs made of serum albumin are referred to SA NPs that possesses several characteristics making
them especially attractive to be considered as a drug delivery system. This review focused on methodologies
actually being used in the synthesis and characterisation of albumin NPs and different author’s opinions on strategic
ways to treat cancerous cell-lines with NPs. Utterly, challenges being overthrown by researchers are brought
up to anneal an effective, all in one targeted albumin NPs to passed through in vitro and preclinical trials.
Keywords: Albumin, NPs, radiation-induced crosslinking, cancer cell-lines, therapeutic-drugs, desolvation.
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