Purpose: The present study aimed to analyze the researches that are at the experimental
phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow
controlled release and imbue small interfering-/micro- ribonucleic acid.
Methods: Without any language preference, we searched US National Library of Medicine National
Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials from 1843 to May 25,
2016 and traced all the references of incorporated documents. The data were evaluated using descriptive
statistics and the results are shown as frequency (%).
Results: We haven’t encountered any drug delivery system in which Small interfering ribonucleic acid/
micro ribonucleic acid oligonucleotides were embedded successfully against osteosarcoma. There has
been only one research in which hairpin-ribonucleic acid was embedded.
Conclusion: It was considered that drug delivery system enabling controlled oligonucleotide release in
the treatment period of osteosarcoma was not projected for the clinical use. However, it cannot be neglected
that the mentioned experimental studies with regard to osteosarcoma treatment establish the basis
of target therapies. The method in question looks promising regarding effective treatment of osteosarcoma
in the future.