Background: Coumarin is an important class of natural products with applications in different areas
of knowledge. Due to its importance, several methodologies and strategies have been developed for the synthesis
of different classes of compounds containing this nucleus.
Objective: The aim of this review is to cover in the last five years the complex fused coumarin derivatives synthesized
in one-pot three-component reactions.
Conclusion: Considering that multicomponent reactions are a powerful tool to produce simple and complex
compounds in one or few steps with high selectivity and yields while following the green chemistry principles.
Keywords: Coumarins, green chemistry, multicomponent reactions, natural products, synthesis, derivatives.
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