Background: A mixture of aspirin and dipyridamole has been proved to significantly reduce
the stroke recurrence. As the use of mixture of aspirin and dipyridamole is increased, the accurate concentration
of each component should be determined to avoid side effects and to improve the treatment
process in pharmaceutical preparation.
Objective: The goal of the present study is the simultaneous determination of aspirin and dipyridamole
mixtures in pharmaceuticals using the chemometrics methods.
Methods: The simultaneous spectrophotometric determination of aspirin and dipyridamole was carried
out using the genetic algorithm as feature selection, coupled with partial least squares for regression
Results: The linearity range of calibration curve was obtained over the range of 30-250 and 1-20
µg·mL-1 for aspirin and dipyridamole, respectively. The results indicated that the developed methods are
of high accuracy and can be used as a simple and fast techniques for analyzing of these compounds.
Conclusion: The developed techniques are simple and with high precision and accuracy can be used in
real samples for pharmaceutical formulation.