Background: Recent years have seen a rise in the number of cancer cases and deaths
worldwide. Emphasis on prevention as an approach for the management of cancer has increased. The
chemopreventive intervention prevents, suppresses, or reverses the initiation of carcinogenesis or the
progression of already initiated, neoplastic cells to invasive cancer. Investigating the effects of potential
preventive interventions is a central goal in cancer preventive research.
Objective: This review aims to present the natural chemopreventive agents with their proposed
mechanism of action to prevent cancer.
Method: Research and review papers were analyzed and the data were compiled to present
the potential mechanisms of various nutraceuticals for chemoprevention. Data was also
obtained from WHO site.
Result: 96 articles including research and review papers were referred which proves various
nutraceuticals to be potential chemopreventive agents. Mechanisms of chemoprevention
were discussed in detail in the research articles. Review articles provided a brief description
of the drugs.
Conclusion: The findings from this review article confirm the potential activities of various
nutraceuticals in prevention of cancer and management strategies. There is need for
more clinical research on the different plant species to identify the active constituents, their possible
mechanisms as well as their potential in the prevention of cancer.