Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism;
recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses
metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.
Objective: To investigate whether the association between vitamin D and leptin is related to markers of
vulnerable plaque, such as MMPs in patients with acute myocardial infarction.
Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty.
Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D
concentrations in serum and MMP-2 and -9 activities in plasma were determined.
Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission
(p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance
of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin
(r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003).
Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are
involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels
would be associated with a worse metabolic profile in acute coronary syndrome patients.