Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction

Author(s): Nahuel Fernandez Machulsky, Magali Barchuk, Juan Gagliardi, Diego Gonzalez, Micaela Lombardo, Alejandro Garcia Escudero, Gerardo Gigena, Federico Blanco, Laura Schreier, Bibiana Fabre, Gabriela Berg*.

Journal Name: Current Vascular Pharmacology

Volume 16 , Issue 4 , 2018

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Graphical Abstract:


Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.

Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction.

Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined.

Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003).

Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.

Keywords: Vitamin D, acute myocardial infarction, matrix metalloproteinases, leptin, non HDL-cholesterol, vulnerable plaque.

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Article Details

Year: 2018
Page: [355 - 360]
Pages: 6
DOI: 10.2174/1570161115666170609102506
Price: $65

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