The Role of Gut Microflora in Obesity - Does the Data Provide an Option for Intervention?
Pp. 204-227 (24)
Parth J. Parekh, Edward C. Oldfield, Amrit Lamba and David A. Johnson
The obesity epidemic has proven to have a significant burden on the current
of state of healthcare. At an individual level, obesity and its sequelae have numerous
effects on the state of health and quality of life. On a global perspective, treatment of
obesity and its sequelae come at a high cost. Obesity, in terms of intestinal dysbiosis, is
a complicated disequilibrium that offers many unclear complications. Thus, restoration
of the commensal microflora serves a potential therapeutic option in combatting the
obesity epidemic be it via antibiotic therapy, probiotics, prebiotics, symbiotics
(combination of prebiotic and probiotic therapy), or fecal microbiota transplant. This
manuscript will review the role of intestinal dysbiosis in the pathogenesis of obesity
and the potential role for microflora manipulation as therapy.
Antibiotics, Butyrate, Dysbiosis, Fecal Microbiota Transplant, FFAR,
Fiaf, Metabolic Endotoxemia, Microbiota, Obesity, Prebiotics, Probiotics,
Proprionate, SCFAs, Symbiotics.
Division of Gastroenterology and Hepatology, Eastern Virginia Medical School, Norfolk, VA 23510, USA.