Liquid chromatography (LC) coupled to an electrochemical (EC) detector is a
complementary analytical tool compared to LC coupled with optical or mass spectrometry
detectors (LC-MS). LC-EC can be applied to the determination of molecules difficult to be
analyzed by other commercially available detectors. New EC detector design and new
working electrode material have extended the scope of application in the field of pharmaceutical
compounds analysis. Combining EC with LC-MS offers additional advantages
compared to optical detectors in terms of drug stability and drug metabolism mimicry studies.
Selected literature devoted to pharmacologically active compounds in their dosage
forms, herbal drugs in natural products, drug residues in feed and/or in biological samples
are reported in this review.
Keywords: Liquid chromatography, electrochemical detector, biomedical, pharmaceutical analysis, bioanalysis,
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