Background: New insights on the relationship between weight loss and hypertension and the role of
the newly approved anti-obesity drugs on hypertension will be discussed
Methods: Weight loss is a major factor to reduce blood pressure when a patient with excess weight is advised
from the health care provider to change his lifestyle. A healthy lifestyle with reduction in body weight, reduction
in caloric intake, increased fruit and vegetables consumption and reduced salt intake concomitant with an increase
in physical exercise can reduce body weight and hypertension in overweight and obese patients, but not all obese
are able to reduce their blood pressure and lose weight without treatment and special dietary care. Moreover, most
obese people lose weight for a small period and then they regain all the weight that they have lost or even worse,
they increase their weight more than before starting a diet. Newly-approved weight loss drugs have variable actions
on high blood pressure. Liraglutide and phentermine/topiramate seem to reduce hypertension, while after the
bupropion/naltrexone or lorcaserin use trials reported a rise in blood pressure.
Conclusion: Reduction in body weight with treatment is not always associated with reduction in obesity induced
hypertension. Weight loss treatments that exhibit sympathomimetic or adrenergic actions should be used with
care and for short periods of time.
Keywords: Obesity, hypertension, obesity-induced hypertension, anti-obesity drugs, liraglutide, bupropion/naltrexone, phentermine / topiramate,
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