Background: Curcumins were reported to possess anti-inflammatory and antiangiogenic.
Furthermore, Curcumin is a very potent free radical scavenger than vitamin E. Moreover,
cyanoacetamides were reported to possess, antimicrobial antifungal, insulin releasing, antiinflammatory
and antitumor. Thus the present study focuses on the synthesis of some novel structure
hybrids incorporating either curcumin or cyanoacetamide with sulphonamide, aiming to reach a
more potent antioxidant agent.
Methods: 4-arylazoenol derivatives 12-16 and E-hydrazo derivatives 19-23 were prepared and their
structure was confirmed by variable spectra analysis. The newly synthesized compounds were screened
for their antioxidant activity using ABTS and Bleomycin-dependent DNA damage methods.
Results: Coupling of the diazonium salts 7-11 of different sulpha drugs with curcumin 1 or with
cyanoacetamide 18 afforded the corresponding 4-arylazoenol derivatives 12-16 and E-hydrazo derivatives
19-23. Among all the synthesized compounds, 12-16, 18, 20 and 22 were the most
potent antioxidant compounds.
Conclusion: The objective of the present study was to synthesize and evaluate the antioxidant
activity of some novel sulfonamides structure hybrids incorporating either curcumin or N-[4-
(aminosulfonyl) phenyl]-2-cyanoacetamide moiety with the hope of discovering new structure serving
as antioxidant agent. The data showed clearly that most of compounds displayed good in vitro