Alzheimer Diseases (AD) is a multifactorial pathology characterized by a complex etiology.
The hallmarks of AD, such as Aβ deposits in senile plaque and Neurofibrillary Tangles (NFT), are
strongly intertwined with Reactive Oxygen Species (ROS) production and oxidative stress (OS), which
are considered the common effectors of the cascade of degenerative events. An increasing body of evidence
reveals that both mitochondrial abnormalities and metal accumulations synergistically act as major
producers of ROS, thus contributing to neuronal toxicity. Consequently, the detrimental role of ROS
production together with the neurodegenerative events involved in AD has been widely investigated as
new potential therapeutic strategies. This review will concisely summarize the link between OS and the
hallmarks of AD, emphasizing on their strong correlation with neurodegenerative events and elucidating
the pivotal role of ROS in AD pathology. Furthermore, through this review, we will provide a short account
of some of the efforts, challenges and opportunities in developing multitarget drugs by addressing
ROS production, metal accumulation and protein depositions.
Keywords: Alzheimer diseases, Oxidative stress, Multitarget-ligand, Neurodegeneration, AD therapy, Hybrid scaffold.
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