Objective: This review article focuses on the neuroprotective effect of drug-induced hypothermia
in cerebrovascular diseases and discusses its related side effects.
Method: A systematic literature search was performed using Pubmed and Embase electronic databases
for a retrospective analysis.
Results: Experimental studies have shown that drug-induced hypothermia alleviates brain damage
and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits.
Therefore, drug-induced hypothermia has an important research value and is worth further consideration
in the clinical setting. However, drug-induced hypothermia is also associated with side effects,
such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte
imbalance, glucose metabolism disorders, and skeletal muscle tremor. Existing drugs with
cooling effects belong to the following categories: (1) dopamine receptor agonists; (2) cannabis; (3)
opioid receptors; (4) vanilloid receptors; (5) vasopressins (potent neurotensin receptor agonists); (6)
thyroid drugs; (7) adenosine drugs; and (8) purine drugs.