Frontiers in Biomaterials

Frontiers in Biomaterials

Volume: 3

Chitosan Based Materials and its Applications

This volume presents 10 reviews contributed by eminent researchers around the world on chitosan based materials. The introductory chapters present information on general characteristics of chitosan ...
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Chemically Modified Chitosan Derivatives

Pp. 107-132 (26)

Adriana Pavinatto, Anderson Fiamingo, Andrea de Lacerda Bukzem, Daniella de Souza e Silva, Danilo Martins dos Santos, Tonimar Arrighi Domiciano Senra, William Marcondes Facchinatto and Sergio Paulo Campana-Filho


Some chemical modifications aiming to introduce a new functionality, to improve and/or develop a given property of chitosan are addressed. Given the great number of possible reactions, focus is put only on some representative chitosan derivatives, exploring examples of those exhibiting anionic, cationic, amphiphilic and hydrophilic character, as well as on crosslinked derivatives. The main synthetic routes used to produce such chitosan derivatives are discussed as well as their structural and physicochemical characterization and some examples of applications in different fields. The effects of the characteristics of the parent chitosan, the locus of chemical modification, the nature and the content of substituent's on the properties of the chitosan derivatives are discussed. Some applications of chitosan derivatives are discussed as well.


Amphiphilic derivatives, Anionic derivatives, Chitosan, Chemical modifications, Cationic derivatives, Genipin-crosslinked N, O-carboxymehtyl chitosan, N, O-carboxymehtylchitosan, N-(2-hydroxyl)propyl-3-trimethylchitosan, N, N, N-trimethylchitosan, N, O-methoxypoly(ethyleneglycol)-g-chitosan.


Instituto de Química de São Carlos – Universidade de São Paulo, Av. Trabalhador são-carlense, 400 – CEP, 13566-590 São Carlos/SP, Brazil.