Background: In the present study, new triazine derivatives 3, 4, 5, 6, 8 and 10 were
synthesized starting from readily available cyanuric chloride 1 via nucleophilic displacement with
morpholine followed by Suzuki or Stille coupling reactions and then the thermal displacement of
chlorine atom with diverse substituted amines.
Methods: All synthesized compounds were screened for their cytotoxic activity against HT-29,
MDA-MB-231, and HEK293 cell lines.
Results and Conclusion: Compounds 6a (IC50 (µM): 0.32 for HT-29 and 2.92 for MDA-MB-231)
and 8c (IC50 (µM): 1.40 for HT-29 and 1.60 for MDA-MB-231) have been identified and compared
with Doxorubicin and ZSTK474 as the reference standards.