Abstract
Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability.
Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release.
Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile.
Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release.
Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.
Keywords: Analysis, biodegradable polymers, hydrogels, polymeric drug carrier, polymeric drug delivery systems, responsive delivery systems.
Current Drug Delivery
Title:Investigation of Methylene Blue Release from Functional Polymeric Systems Using Dielectric Analysis
Volume: 15 Issue: 1
Author(s): Marcos Luciano Bruschi*, Mariana Volpato Junqueira, Fernanda Belincanta Borghi-Pangoni, Tao Yu, Gavin Paul Andrews and David Simon Jones
Affiliation:
- Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, State University of Maringa, Maringa, Parana,Brazil
Keywords: Analysis, biodegradable polymers, hydrogels, polymeric drug carrier, polymeric drug delivery systems, responsive delivery systems.
Abstract: Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability.
Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release.
Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile.
Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release.
Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.
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Cite this article as:
Bruschi Luciano Marcos *, Junqueira Volpato Mariana, Borghi-Pangoni Belincanta Fernanda, Yu Tao , Andrews Paul Gavin and Jones Simon David , Investigation of Methylene Blue Release from Functional Polymeric Systems Using Dielectric Analysis, Current Drug Delivery 2018; 15 (1) . https://dx.doi.org/10.2174/1567201814666170602074650
DOI https://dx.doi.org/10.2174/1567201814666170602074650 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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