Aim and Objective: Enaminones belay to be extremely stable compounds and constitute a versatile
group of salutary precursors for the synthesis of enormous classes of organic compounds. So, in this context,
we synthesized a new enaminone, namely, (E)-3-(dimethylamino)-1-(8-phenyl-8H-[1,2,4]triazolo[4,3-
a]perimidin-10-yl)prop-2-en-1-one (enaminone 2).
Materials and Methods: The reaction of enaminone 2 with different types of hydrazonoyl chlorides or hydrazine
hydrate afforded new substituted pyrazoles. Also, the reaction of enaminone with 6-amino-2-
thioxopyrimidin-4-one in acetic acid under reflux produced 2-thioxopyridopyrimidinone derivative. The latter
thione derivative reacts with hydrazonoyl chlorides to give pyridotriazolopyrimidines. 5-(8-Phenyl-8H-
[1,2,4]triazolo[4,3-a]perimidin-10-yl)isoxazole was produced from the reaction of enaminone 2 with hydroxylamine.
Results & Conclusion: The structure of all the novel perimidine derivatives was confirmed on the basis of
spectral data and elemental analyses. The enaminone and the newly synthesized compounds were tested for
their antimicrobial activity, and the results obtained revealed that some derivatives are more potent than the
reference drugs used.