Epigenetics in Odontogenesis and its Influences

Title:Epigenetics in Odontogenesis and its Influences

Volume: 13 Issue: 2

Author(s): Chuwen Li, Yujia Cui, Changchun Zhou, Jianxun Sun*Xuedong Zhou

Affiliation:

• State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University - Endodontics and Operative Dentistry, Chengdu,China

Keywords: Odontogenesis, epigenetics, microRNA, DNA methylation, histone modification, apoptosis.

Abstract: Background: Odontogenesis is fundamentally controlled by the genome. However, epigenetic factors have indispensable effects during odontogenesis. Previous studies have shown that exogenous factors, such as the environment, that cause hypomethylation and hypermethylation in DNA may lead to dental differences in monozygotic twin pairs. In addition, abnormalities in epigenetic regulation could induce disruptions in odontogenesis, thereby causing tooth malformation or agenesis.

Objective: This review overviews the epigenetic mechanisms involved in odontogenesis with the aim of establishing a fundamental vision of tooth development, which might be useful in further research in odontogenesis and therapy for dental diseases.

Results: We summarized articles about epigenetics in odontogenesis. Here, we present concrete epigenetic regulation mechanisms in odontogenesis that have been reported previously, following the order of microRNA, DNA methylation and histone modification.

Conclusion: Epigenetic factors influence the proliferation, differentiation or apoptosis of cells that play indispensable roles during the process of odontogenesis which have the ability to exquisitely regulate the tooth number, size and shape.

Cite this article as:

Li Chuwen , Cui Yujia , Zhou Changchun, Sun Jianxun*, Zhou Xuedong , Epigenetics in Odontogenesis and its Influences, Current Stem Cell Research & Therapy 2018; 13 (2) . https://dx.doi.org/10.2174/1574888X12666170530100524